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E2 Elimination: Zaitsev vs Hofmann Explained #mcat #organicchemistry #orgo
E2 elimination broken down step by step. Same substrate, two different bases, two completely different products. NaOEt with heat → Zaitsev product (more substituted alkene) tBuOK → Hofmann product (less substituted alkene) Three requirements: strong base, anti-periplanar geometry, no intermediate. Full mechanism walkthroughs and practice ...
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